I haven't changed careers but I did recently change fields. It was a huge adjustment. Although the basics are the same and versatile, learning a completely new industry, terminology, procedures, corporate culture, etc. was quite an adjustment.
It was a better company, more money and an opportunity that was too good to pass up.
I have never once regretted it. Deep down, you know when it's time. You just have to shut your eyes, take a deep breath and jump. It is scary as $#it, but once you land, it's worth it, at least it was for me. 4951